Five Washington players scored in double figures with Jamaal Williams producing 19. Washington (10-1) won its sixth straight and will next play in its Pac-10 Conference opener against California on New Year's Eve.
The Huskies lone loss came against Gonzaga.
Houston fell to 8-4. The Cougars were led by Chris Lawson with 18.
Washington opened a 23-9 lead and was never threatened.