Toronto ended a seven-game losing streak. Morris Peterson added 19 points and the Raptors overcame a three-point deficit to start the fourth period with a 16-2 run.
The Timberwolves made just four field goals in the fourth quarter and lost for the third time in 11 games. Kevin Garnett scored 23 points to pace Minnesota.
Toronto's Matt Bonner was thrown out of the game during the Raptors' fourth-quarter run because of a flagrant foul against Garnett.
When Bonner shoved Garnett to the floor, Latrell Sprewell rushed to his teammate's aid. But the game officials prevented the incident from getting out of hand.