Chandler guided the Rams to a 16-6 win over San Francisco last week after Marc Bulger suffered a sprained right shoulder.
Chandler, 39, was 18-of-27 for 216 yards with one touchdown pass. The 16-year veteran, who signed as a free agent in March, did not have an interception and was not sacked.
"I am excited about the potential of what he (Chandler) can do for us this week," said Coach Mike Martz.
Chandler, who also has played for Indianapolis, Tampa Bay, Phoenix, Houston, Atlanta and Chicago, will be making his 151st career start.