Bryant earned $630,000 for the victory.
Patrick Sheehan closed with a 66 to take second place at 19-under-par 261. Dean Wilson, the second round leader, also posted a final-round 66 to share third place, at 15-under-par 265, with Todd Fischer, who had a closing 67.
"My ball-striking has always been the thing that's carried me through. This week it was a little above average," said Bryant. "I hit the ball extremely well. Then I had that one day where I putted awfully well. I didn't miss anything Saturday (when he had a 60)."
Bryant is playing the season on a major medical extension. He has had surgeries on both elbows and his shoulder since being an exempt player in 1992.