Tampa Bay had a franchise-record six-game winning streak halted with Tuesday night's 2-1 setback against Washington. But the Lightning wasted little time getting back in a groove, scoring three times in the opening 25:17.
Denis Arkhipov had both goals for the Predators, who have dropped two straight games since an 11-game unbeaten streak at the Gaylord Entertainment Center.
All-Star goaltender Tomas Vokoun had another rough outing, allowing four goals on 28 shots.
Nashville fell to 17-7-4-1 at home.