Third among rookies in scoring behind highly touted LeBron James and Carmelo Anthony, Wade was placed on the injured list Friday after undergoing an MRI. He is expected to wear a cast for at least two weeks.
"Once the swelling went down, then I really got a chance to see how sore it really was," Wade said. "I can't shoot or anything."
The 6-4 Wade is averaging 16.2 points and a team-leading 4.4 assists in 29 games this season. He also leads the Heat with a .453 field goal percentage and 1.28 steals per game.
The fifth pick in the 2003 draft, Wade originally hurt the wrist in a fall during Miami's win at Washington on Dec. 26.
Pregnant Mila Kunis wins 'Best Villain' at MTV Movie Awards
Charlize Theron not engaged to Sean Penn 'yet'