Against Atlanta last Sunday, he became the fifth quarterback in league history to throw five or more touchdown passes twice in the same season by throwing five in the Colts' 38-7 victory.
With the win, Indianapolis (11-3) clinched its fourth postseason berth in five years.
Manning completed 25-of-30 attempts for 290 yards without an interception.
"It's a good thing we've got Peyton," said running back Edgerrin James. "He's 'The General' out there. He's controlling everything."
Manning was AFC Offensive Player of the Week. He was joined in the AFC by tackle Rod Coleman of Oakland (defense) and placekicker Jason Elam of Denver (special teams).