Lee, the fourth-year receiver had five catches for 91 yards, including his first touchdown of the year, a nifty catch-and-run down the right sideline with 3:37 left in the half.
Lee had not caught a pass this season but he and Keenan McCardell -- who had nine catches for 83 yards -- helped offset the loss of Keyshawn Johnson, the all-pro receiver.
Former Giant Joe Jurevicius added three catches in extended action for the defending Super Bowl champions.
Tampa Bay attempted to run out the clock late in the game but when the Giants stopped Michael Pittman on a fourth-and-inches deep in New York territory, the Bucs defense had to step up.
The Giants have dropped three straight and six of eight.