Both schools are 6-1 in Big Ten play. The fourth-ranked Buckeyes (10-1) seek three straight wins over the fifth-ranked Wolverines (9-2) for the first time since winning four in a row from 1960-63.
The game not only will decide the Big Ten title, but Ohio State's hopes of playing for a second straight national title also hang in the balance.
"Our goal is the Big Ten championship, and this is definitely the Big Ten championship game," said Michigan quarterback John Navarre.
Elsewhere, it's top-ranked Oklahoma at Texas Tech, UCLA at Southern California, LSU at Mississippi, Kentucky at Georgia, Washington State at Washington, Vanderbilt at Tennessee, Boston College at Virginia Tech, Rutgers at Miami, Purdue at Indiana, Iowa at Wisconsin, Missouri at Kansas State, Miami (Ohio) at Ohio, Boise State at Fresno State (Friday), Pittsburgh at Temple, Oklahoma State at Baylor, and Bowling Green at Ball State.