Hand, acquired in April, has been hampered by a groin injury and a bruised toe this season, and managed just 10 tackles and one sack in six games. He tore the biceps muscle in a Nov. 2 win over Pittsburgh and missed last Sunday's 27-20 loss at Washington.
Hand, 31, likely will become the fourth member of the Seahawks to go on injured reserve and second defensive tackle. Fourth-year player Cedric Woodard and rookie Rashad Moore are the starters at the defensive tackle positions for Seattle with veteran John Randle moving in on passing downs.
"When you lose somebody, he's always going to be missed," Randle told the Seattle Times. "It hurts our rotation a little bit, but you know, the next guy has to step it up."
The 6-3, 310-pound Hand started 74 games over the last five seasons, two with San Diego and three with New Orleans.