With the Chargers tied for the NFL's worst record, Coach Marty Schottenheimer turned to the 41-year-old Flutie to replace Drew Brees as his starting quarterback.
Flutie passed for two touchdowns and ran for a score in the first half as the Chargers (2-7) scored on all four of their possessions to build a 28-14 lead. Flutie finished 21-of-29 for 248 yards.
LaDainian Tomlinson offered Flutie some help as he rushed for 162 yards and two touchdowns. His first score was a 73-yard run in the first quarter.
It was the third straight loss for the Vikings (6-3) although Daunte Culpepper completed 32-of-44 passes for 370 yards snd four touchdowns.