Green Bay quarterback Brett Favre, who was making his first appearance in St. Louis since his nightmare performance in a January 2002 divisional playoff game, dropped to just 10-20 in domes.
The Rams converted four Green Bay turnovers into 17 points and were never seriously threatened after opening a 14-3 lead in the first period.
Dane Looker gave the Rams a 28-17 lead with 4:14 left in the third quarter with a 20-yard scoring reception, tiptoeing along the left sideline.
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