The winless Jaguars have struggled in the passing game in Smith's absence. He was suspended by the league for the first four games of the regular season on Aug. 16 for violating the league's substance abuse policy.
"I would like to begin by reiterating how truly sorry I am," Smith said. "Actions speak louder than words, and I understand that it is up to me to show you, not tell you, how sorry I am."
The Jaguars have lost their first four games for the first time since the franchise's inception in 1995.
In 2001, he was pulled over on suspicion of drunk driving and was found to have cocaine in his system, although the charges were dropped.
Smith, 34, who started his career with Dallas in 1992, has had at least 1,000 yards receiving in seven straight seasons. Last season, he had 80 receptions for 1,027 yards and seven touchdowns.
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