Andy Pettitte (16-7) earned his 1th win in his last 12 decisions. Soriano hit a 2-0 pitch from starter Damian Moss over the center field fence for his 28th homer of the year. He broke Rickey Henderson's 1986 team record for leadoff blasts and climbed within two of Brady Anderson's major league mark.
Soriano also capped the scoring -- and his first four-hit game since April 23 -- in the eighth with a two-run single.
The Yankees got a scare in the bottom of the sixth when All-Star first baseman Jason Giambi was hit on the right hand by a pitch from reliever John Parrish. Giambi was in obvious pain, but X-rays were negative.