It was the team's lone exhibition contest before its quest to qualify for the 2004 Olympics, which begins Wednesday at the FIBA Tournament of the Americas in Puerto Rico.
Duncan led six players in double figures with 21 points, and added 15 rebounds, powering Team USA to a staggering 54-23 advantage on the glass.
"I'm just worried about rebounding the ball and trying to defend," Duncan said. "Where I'm getting most of my stuff is in transition or on broken plays."
Carlos Arroyo of the Utah Jazz scored 18 points and Elias Ayuso added 14 for Puerto Rico, which trailed by as many as 28 points.