In an interview Sunday while at a celebrity golf tournament near Lake Tahoe, Sampras indicated he will withdraw from the upcoming U.S. Open.
He won that event last year, beating long-time rival Andre Agassi to snap a two-year tournament-winning drought, and hasn't played in a major this year.
"Not being at the Open this year, which I'm going to pull out of, and not playing Wimbledon, I don't miss it enough to really start training, start practicing, doing everything I have to do to be where I want to be," Sampras said. "So it tells me it's a sign to say, 'It's probably time'."
Sampras, 31, set an ATP record by finishing No. 1 in the world rankings for six straights years.
In his career, he has won Wimbledon five times, the Open five times, and the Australian Open twice. He has an overall record of 762-222 and a record 64 singles crowns.