Cincinnati 6, NY Yankees 2

CINCINNATI, June 4 (UPI) -- A season-high four different players homered against Mike Mussina Wednesday night as the Cincinnati Reds clinched their first interleague series against the New York Yankees with a 6-2 decision.

Aaron Boone, Sean Casey, Ken Griffey Jr. and Jason LaRue each hit a home run against Mussina (7-4), who fell to 0-4 in his last five starts after winning his first seven.

New York's Jason Giambi also homered at the new ballpark, which has surrendered a major league-high 91 homers this season.

The Yankees - who lost for the eighth time in 12 games - took a 2-0 lead on Giambi's two-out homer against Paul Wilson (3-4) in the top of the third. It was Giambi's second of the series and fourth in five games.

But the Reds halved the deficit with Boone's solo shot with two outs in the bottom of the frame.

As Wilson got sharper as the game progressed, Mussina got hit harder. With two outs in the fifth, Adam Dunn singled and narrowly stole second. Casey and Griffey followed withback-to-back homers to give the Reds a 4-2 cushion.

Griffey's blast was the 475th of his career, tying Stan Musial and Willie Stargell for 22nd on the all-time list.

The oft-injured Griffey strained his right biceps on the swing and exited the contest as a precautionary measure.

LaRue capped the scoring with a two-run shot in the sixth.

Wilson gave up two runs and seven hits in seven frames to become the first Reds starter to win a game since Danny Graves blanked St. Louis on May 14th, a span of 17 games.

The Yankees managed just two hits after the third inning and none after Hideki Matsui's one-out double in the fifth.