Antropov suffered a right foot injury in the second period when a slap shot by Philadelphia defenseman Eric Desjardins struck his skate. After Desjardins scored on a rebound, Antropov left the ice and returned to the locker room.
Best known for his questionable hit on New York Islanders captain Michael Peca in last season's playoffs, Tucker was sideswiped by Flyers defenseman Eric Weinrich midway through the first period, and immediately went for medical attention. The extent of his injury is unknown.
Neither player returned, and both are questionable for Game Two, which is Friday in Philadelphia.
"It does appear that Nik broke that bone that (Phil) Housley broke," said Toronto Coach Pat Quinn, referring to the fractured foot his defenseman suffered in February. "With Tucker, we'll do an MRI (Thursday) and see how extensive the damage was there."
The Maple Leafs already are without defenseman Glen Wesley and centers Travis Green and Doug Gilmour. Wesley is sidelined with a broken foot, but may return for Game Three, while Green is day-to-day with a rib injury.
Gilmour suffered an injured left knee in his first game after being re-acquired from Montreal at the trade deadline. He is not expected back before the conference semifinals.