Before the game, Hull was honored for reaching 700 goals and 600 assists. Team owner Mike Ilitch and wife Marian presented Hull with a silver stick and everything he touched during the game turned to gold.
Hull scored twice in the second period. His second goal - a snap shot from the left faceoff dot - gave Detroit the lead for good, 3-2, with 9:13 left in the period.
The Red Wings scored three goals on four shots in the second period and left it with a 4-2 lead. Hull tallied on consecutive shots in an 8:17 span.
Hull finished the scoring with 44 seconds left in the game, putting a patented one-timer inside the left goalpost from the high slot to beat Ray Emery, who was making his NHL debut.
Emery stopped six of the seven shots he faced in place of Patrick Lalime, who was pulled immediately following Hull's second goal. He allowed five goals on 13 shots.
Defenseman Nicklas Lidstrom and rookie Henrik Zetterberg added power-play goals for the Red Wings, who won their fourth straight overall, claimed their eighth in a row at home and moved a point ahead of Dallas in the West.
Marian Hossa scored his team-best 42nd goal for the Senators, who lost for the second time in as many days following a five-game winning streak. They lead Detroit by two points for first overall in the league.