Marquette (23-4, 14-2 C-USA American) finished one game ahead of Memphis for the league crown. The Golden Eagles became the first team other than Cincinnati (17-10 9-7) to win the regular-season title in the eight-year history of the league.
Wade made just two of six shots and committed four turnovers in the first half as Marquette trailed, 33-29. The Golden Eagles shot just 37 percent over the first 20 minutes.
Marquette used a 16-6 run to open the second half and take command, seizing a 45-39 advantage. Wade scored nine points in the spurt, including a thunderous dunk to cap it.
Tony Bobbitt scored 13 points for Cincinnati, which lost for the seventh time in 11 games.