After four seasons in Toronto, Joseph signed with Detroit in the offseason. He sat out the Red Wings' 2-1 victory at the Air Canada Centre on Nov. 16 but turned aside 27 shots in this one to help the defending Stanley Cup champions improve to 7
Zetterberg and Hull got their second goals of the night in an 8:22 span of the second period after the Maple Leafs closed within 3-2.
Kris Draper and rookie defenseman Dmitri Bykov tallied in the third to complete the scoring for Detroit, which moved four points ahead of second-place St. Louis in the Central Division.
It was the most lopsided loss of the season for Toronto.