White went down with just over 13 minutes left in the second period. He tried to check Mike Fisher in the neutral zone but turned and fell awkwardly, bending back his lower right leg in a gruesome position.
As play continued momentarily, White tried to crawl to the bench on his hands and knees.
"Obviously, you know it's something serious," Devils captain Scott Stevens said. "He usually gets up from most things, so you knew it was a serious thing."
The team announced that White was taken to a hospital for x-rays, the results of which would be disclosed Thursday. But teammates were expecting the worst.
"He's been having a great season, so not having him around would be tough," goaltender Martin Brodeur said. "Physically, and the way he was moving the puck, he's been a great asset for our team."
White, 25, has five goals and seven assists in 59 games and his plus-17 rating is second on the team. His loss would be the third in as many weeks for a team that was relatively injury-free over the first four months of the season.
Versatile winger Sergei Brylin has missed seven games with a fractured wrist and right wing Turner Stevenson went down with a knee injury on Feb. 12. Also, defenseman Oleg Tverdovsky has missed 16 games with concussion-like symptoms and right wing Brian Gionta aggravated an ankle injury Saturday.
"We have some depth here, which is good," Stevens said. "But when you lose Brylin and Turner and Colin, it's tough. Hopefully, we'll get Brylin back and Colin back by the end of the year."