Under control of the NHL after owner John Rigas was indicted on fraud charges during the offseason, the Sabres made Vezina and Hart Trophy winner Jose Theodore look ordinary, torching him for six goals on 31 shots.
Pyatt opened the scoring, banging in Chris Gratton's cross-crease pass at 2:11 of the second period before giving Buffalo a 3-1 lead by knocking in a rebound from low in the slot.
Tim Connolly had a goal and an assist and Gratton and J.P. Dumont each added two assists for the Sabres, who have not lost in Montreal since Oct. 17, 2000.
Biron was solid, allowing just defenseman Patrice Brisebois' slap shot early in the second period to elude him.
2014: The Year in Music [PHOTOS]