The Buckeyes (2-0) led 21-0 after one quarter and built a 38-0 advantage midway through the second period before coasting the rest of the way.
Clarett burst on the college football season by running for 175 yards and three touchdowns in a win over Texas Tech two weeks ago. He opened the scoring Saturday with a two-yard run in the first quarter and caught a seven-yard TD pass from Craig Krenzel early in the second quarter.
Clarett carried 12 times for 64 yards and played sparingly in the second quarter.
Krenzel completed 12-of-14 passes for 190 yards and one score. He tied a school record with 12 straight completions, set most recently by Mike Tomczak in 1983.
Safety Mike Doss and linebacker A.J. Hawk returned interceptions for scores for the Buckeyes, who complete a three-game homestand next week by hosting No. 12 Washington State.
Clarett's first score 2:44 into the game followed a blocked punt on Kent State's first possession. Less than three minutes later, All-America safety Doss picked off a pass from Joshua Cribbs and returned it 45 yards for a score.
Maurice Hall scored on a 28-yard run to increase the lead to 21-0.
Clarett caught a TD pass from Krenzel to make it 28-0 and Mike Nugent followed with a 41-yard field goal. Hawk returned an interception 34 yards for a score with 7:31 left in the half to push the lead to 38-0.
Kent State finally showed some life late in the second quarter when Cribbs threw TD passes of 28 yards to Daryl Moore and eight yards to Antonio King.
The only score of the third quarter was a 33-yard field goal by Nugent.
Cribbs carried 21 times for 94 yards and completed 14-of-31 passes for 160 yards for Kent State (1-1).