Prior to Saturday night, Wilson (4-7) had three wins against the Baltimore Orioles but was winless in seven decisions against everyone else. The righthander has won his last two starts after losing four in a row.
Wilson was aided by a five-run third inning. Felix Escalona plated rookie Carl Crawford with a groundout, Steve Cox had a run-scoring single and Jared Sandberg an RBI double before Jason Conti capped the outburst with a two-run base hit.
Chicago stater Todd Ritchie (5-15) allowed six runs and 10 hits in six innings and had his losing streak extended to five games.
The righthander is 1-10 on the road this season.