Detroit slipped to 0-8 and matched its worst start in 50 years. New Detroit manager Luis Pujols contributed to the setback by being late to yank starter Jose Lima in the game-turning fifth inning.
Detroit last dropped its first eight games in 1952. The Tigers matched that by opening the season with six losses under manager Phil Garner, who was fired on Monday, and being swept in a rain-shortened, two-game series under Pujols.
Pujols has been named manager for the remainder of the year.
Only 14,155 watched Wednesday's game after 11,833 attended Tuesday night.
The homer by Thomas was his third in as many games and gave the White Sox a 6-3 lead. Chicago continued its domination of the Tigers, having won 15 of the last 17 meetings.
Kenny Lofton had three hits, including an RBI single in the fifth, stole two bases and scored two runs for the White Sox.
Randal Simon hit a two-run homer and Young and Bobby Higginson had solo blasts for the Tigers, who left 13 runners on base.