Terms of his contract were not disclosed.
Reynolds built an impressive 110-35 record at San Bernardino with three California College Athletic Association titles in five years at the school. This season, San Bernardino was 28-2 and reached the "Elite Eight" before falling to eventual champion Metro State. The Coyotes also made the regional finals in 1999.
Reynolds replaces Wayne Morgan, who resigned after posting a 91-84 record over six seasons.
The 48-year-old Reynolds came to San Bernardino after 16 years as an assistant at his alma mater UC Riverside, under Coach John Masi.
The hiring following a recent pattern of highly successful Division II coaches finding work in the Big West Conference.
UC Irvine coach Pat Douglass and Santa Barbara coach Bob Williams won national titles at the Division II level.