Zeile and Uribe smacked two doubles apiece and Jose Ortiz homered for the Rockies, who took a 10-4 lead in the fifth inning.
Denny Neagle notched the win despite giving up eight runs and 11 hits over five innings. Jose Jimenez tossed a perfect ninth for his fourth save.
Tony Graffanino, Sandy Alomar and Magglio Ordonez all homered for Chicago. It was Ordonez's fifth spring homer.
Loser Jon Garland was tagged for 10 runs and 12 hits over 4 2/3 innings.