It was just the second trip to the boisterous Shoemaker Center for Louisville Coach Rick Pitino, who is in his first season as Louisville coach. He guided Kentucky to a 75-71 win here during the 1990-91 campaign.
Saturday's matchup featured two of the winningest active coaches in the nation. Cincinnati's Bob Huggins is sixth in winning percentage with a mark of 486-169 and Pitino is seventh at 363-129.
The game also was a homecoming for Louisville assistant Mick Cronin, who served under Huggins the previous four seasons.
Field Williams added 18 points for the Bearcats (17-1, 5-0 CUSA), who have not lost since their season opener. Their 17-game run is the third longest in school history.
Reece Gaines had 19 points for the Cardinals (11-5, 2-3), who shot 27 percent from the field and dropped to 2-4 following an eight-game winning streak.