On the women's side, the top four seeds, led by defending champion Jennifer Capriati, were still alive. Top-seeded Capriati defeated fellow American Meilen Tu, 6-1, 6-3.
Roddick fell on an already injured right ankle in losing a first-set tiebreaker to Croatia's Ivan Ljubicic, forcing him out of tennis' first Grand Slam of the year. He had injured his ankle in a first-round victory over Mariano Zabaleta then aggravated the injury after running wide for a forehand and tumbling awkwardly while trying to plant his right foot. Accoring to Roddick, the hard surface had something to do with
Prior to getting hurt, Roddick held an 8-7 advantage in the tiebreaker, which he lost, 13-11. He trailed 2-3 in the second set before pulling out. The U.S. teenager gained attention last year in his first fullseason on the ATP Tour. At 19 years, four months, Roddick wonthree titles and finished the year ranked 16th -- the youngestplayer ever to finish in the top 20.
Arnaud Clement of France, last year's finalist, joined Roddick on the sidelines as the No. 15 seed was beaten by Argentine Gaston Gaudio, 6-4, 4-6, 6-2, 7-6 (7-1).
Seventeenth-seeded Carlos Moya of Spain was ousted by German Gaston Gaudio, 6-4, 4-6, 6-2, 7-6 (7-1).
Seventh seed Tommy Haas of Germany and Russian and ninth seed Marat Safin of Russia, the 2000 U.S. Open winner, avoided the upset bug in the second round.
Haas, a semifinalist here in 1999, rolled past French qualifier Jean-Francois Bachelot, 6-1, 6-2, 6-3. Safin saved four set points in the second-set tiebreaker on his way to beating Belgium's Christophe Rochus, 6-2, 7-6 (8-6), 6-1.
Eleventh seed Roger Federer also advanced to the third round, cruising to a 6-2, 7-5, 6-4 victory over Attila Savolt.
On the women's side, fourth seed Kim Clijsters of Belgium advanced to the third round Thursday with a 6-1, 6-1 rout of Austria's Barbara Schwartz.
No. 6 Justin Henin also moved on with a hard-fought 6-3, 3-6, 6-1 victory over Marta Marrero of Spain. Seventh seed and 1999 finalist Amelie Mauresmo of France disposed of Katarina Srebotnik of Slovakia, 7-5, 6-3.
6-1, 4-0 (retired); Wayne Ferreira ousted David Nalabandian of Argentina, 6-7 (5-7), 7-6 (7-2), 7-5, 6-3; Marcelo Rios of Chile bested Karol Kucera of Slovakia, 7-6 (7-5), 7-5, 6-2; Spaniard Albert Costa got past Byron Black of Zimbabwe; 6-1, 6-4, 6-4; and Mikhail Youzhny of Russia rolled by American Mardy Fish, 6-4, 6-3, 6-2.
On the women's side, No. 16 Iroda Tulyaganova of Uzbekistan beat Svetlana Kuznetsova of Russia, 6-4, 6-1; No. 20 Rita Grande of Italy got by Kristie Boogert of the Netherlands, 6-4, 6-1; No. 23 Magui Serna of Spain disposed of Italian Maria Elena Carerin, 6-3, 6-3; No. 24 Ai Sugiyama of Japan rolled by Slovakian Tina
Pisnik, 7-6 (7-2), 6-2; Eleni Daniilidou of Greece ousted No. 29 Tatiana Panova of Russia, 6-2, 4-6, 6-0; Slovakian Janette Husarova defeated Croatian Iva Majoli, 6-4, 6-3; Australian Nicole Pratt took care of Martina Muller of Germany, 6-1, 6-2;
Marlene Weingartner of Germany defeated Italian Antonella Serra Zanetti, 6-4, 6-2; and Australian Cindy Watson needed three sets to beat Emmanuelle Gagliardi of Switzerland, 3-6, 7-5, 6-2.
Swim Week Miami Beach 2014 [PHOTOS]