Wade, named the most outstanding player in the Great Alaska Shootout last month, came into the game averaging a team-high 20 points per game.
Cordell Henry added 14 points for the Golden Eagles (8-0), who are off to their best start since opening the 1997-98 campaign with 10 wins.
Marquette has been especially stingy at home, holding five opponents to an average of 53.6 points per outing.
The Golden Eagles struggled early and had only a 34-29 lead at the intermission, but they outscored Dayton, 39-22, in the second half.
Ramid Marshall and David Morris paced the Flyers (3-3) with 10 points apiece.
Dayton is 3-0 at home, but dropped to 0-3 on the road, also losing at Villanova and Cincinnati.
Marquette avenged a pair of close losses to the Flyers the last two seasons. Dayton posted a 61-60 home victory last season and a 63-60 win in the last meeting in Milwaukee during the 1999-2000 campaign.