Broncos coach Mike Shanahan announced at an afternoon news conference that Davis would undergo surgery later Monday for a torn meniscus and be sidelined for seven to 10 days. He added that the oft-injured back, who has missed 30 of the club's last 42 games, would "probably be sidelined for two games."
The latest injury comes just one day after Davis carried 33 times for 83 yards in a 26-16 victory over the San Diego Chargers.
In September, Davis underwent right knee surgery and missed six games before returning on November 5 at Oakland. He rushed for 70 yards on 17 attempts against the Raiders and looked to be regaining his old form.
Davis rushed for more than 2,000 yards in 1998 but has been hampered by injuries since. He tore his right anterior cruciate ligament in the fourth game of the 1999 season, sidelining him for the rest of the year. In 2000, he missed 11 games, including a playoff loss at Baltimore, due to ankle and calf problems and a stress reaction in his lower left leg.
This season, Shanahan selected Davis as the starter over Olandis Gary and Mike Anderson, who each have had 1,000-yard seasons as rookies filling in for their injured teammate.
Davis had 101 yards on 21 carries in Denver's season-opening 31-20 win over the New York Giants on September 10 before undergoing surgery three days later to repair a small cartilage tear in his right knee.
In 1998, Davis became just the fourth player to eclipse 2,000 yards, rushing for 2,008 yards, winning NFL Most Valuable Player honors and leading the Broncos to their second straight Super Bowl title.
After Davis went down in 1999, Gary rushed for 1,159 yards in 12 games as a rookie.
Last year, Davis had just 282 yards on 78 carries in five games. Gary suffered a torn ACL in the season opener and Anderson came on to rush for 1,500 yards and 15 touchdowns as a rookie.
A three-time AFC rushing champion, Davis is Denver's all-time leading rusher with 7,170 yards and 60 touchdowns in just 73 career games.