Boggs, 43, was named to the position prior to the 2001 season after spending one year in Tampa Bay's front office as special assistant to the general manager. He retired as a player in 1999.
"I'm at a point right now in my life where my family needs me to be around much more than baseball allows me to be," Boggs said. "But I am going to leave the door open to return to the game sometime down the road."
A Tampa , Boggs spent the final two years of his 18-year career with the Devil Rays and collected his 3,000th hit in a Tampa Bay uniform. He ranks 22nd on the all-time hits list with 3,010.
"Speaking on behalf of the entire organization, I would like to thank Wade for everything he has done for us as a player, member of the front office and as a major league coach," Tampa Bay general manager Chuck LaMar said.
The Devil Rays also named Tim Foley third base coach and Jackie Brown pitching coach.