San Francisco VS St. Louis
| Scoring Summary |
| First Quarter |
| St. Louis Touchdown - 18-yard run by Kellen Clemens. (Josh Brown extra point is good). |
| San Francisco Touchdown - 8-yard run by Alex Smith. (David Akers extra point is good). |
| Second Quarter |
| San Francisco Touchdown - 28-yard pass from Alex Smith to Michael Crabtree. (David Akers extra point is good). |
| San Francisco Field Goal - 36-yarder by David Akers. |
| Third Quarter |
| St. Louis Field Goal - 49-yarder by Josh Brown. |
| San Francisco Touchdown - 14-yard pass from David Akers to Michael Crabtree. (David Akers extra point is good). |
| Fourth Quarter |
| St. Louis Field Goal - 48-yarder by Josh Brown. |
| San Francisco Touchdown - 1-yard run by Anthony Dixon. (David Akers extra point is good). |
| Individual Statistics |
| Rushing |
| San Francisco |
Kendall Hunter 16-76, Anthony Dixon 8-21, Frank Gore 7-9, Alex Smith 5-4 |
| St. Louis |
Steven Jackson 16-76, Kellen Clemens 2-18, Cadillac Williams 7-17 |
| Passing |
| San Francisco |
Alex Smith (21-31), Yards: 219, Sacked: 3, TD: 1, David Akers (1-1), Yards: 14, Sacked: 0, TD: 1 |
| St. Louis |
Kellen Clemens (14-31), Yards: 226, Sacked: 3, TD: 1, Tom Brandstater (0-2), Yards: 0, Sacked: 0, TD: 0, Jerious Norwood (0-1), Yards: 0, Sacked: 0, TD: 0 |
| Receiving |
| San Francisco |
Michael Crabtree 9-92, Vernon Davis 8-118, Kendall Hunter 2-11, Brett Swain 1-6, Anthony Dixon 1-6, Bruce Miller 1-0, Joe Hastings 0-0, Justin Peelle 0-0 |
| St. Louis |
Brandon Lloyd 6-100, Lance Kendricks 3-54, Danario Alexander 3-36, Brandon Gibson 1-21, Steven Jackson 1-15, Cadillac Williams 0-0, Kellen Clemens 0-0, Quinn Porter 0-0 |
