| Scoring Summary |
| First Quarter |
| Pittsburgh Touchdown - 1-yard run by Rashard Mendenhall. (Jeff Reed extra point is good). |
| Pittsburgh Touchdown - 19-yard pass from Ben Roethlisberger to Mewelde Moore. (Jeff Reed extra point is good). |
| Second Quarter |
| Pittsburgh Touchdown - 2-yard run by Rashard Mendenhall. (Jeff Reed extra point is good). |
|
| Third Quarter |
| Pittsburgh Touchdown - 6-yard pass from Ben Roethlisberger to Heath Miller. (Jeff Reed extra point is good). |
| San Diego Touchdown - 3-yard pass from Philip Rivers to Antonio Gates. (Nate Kaeding extra point is good). |
| Fourth Quarter |
| San Diego Touchdown - 41-yard fumble return by Jacob Hester. (Nate Kaeding extra point is good). |
| Pittsburgh Touchdown - 6-yard pass from Mewelde Moore to Heath Miller. (Jeff Reed extra point is good). |
| Individual Statistics |
| Rushing |
| San Diego |
LaDainian Tomlinson 7-15, Philip Rivers 1-1 |
| Pittsburgh |
Rashard Mendenhall 29-165, Santonio Holmes 1-7, Ben Roethlisberger 4-3, Mewelde Moore 2-2 |
| Passing |
| San Diego |
Philip Rivers (21-36), Yards: 254, Sacked: 3, TD: 3 |
| Pittsburgh |
Ben Roethlisberger (26-33), Yards: 333, Sacked: 3, TD: 2, Mewelde Moore (1-1), Yards: 6, Sacked: 0, TD: 1 |
| Receiving |
| San Diego |
Antonio Gates 9-124, Vincent Jackson 4-56, Chris Chambers 4-39, Legedu Naanee 2-20, Darren Sproles 1-16, LaDainian Tomlinson 1--1 |
| Pittsburgh |
Hines Ward 8-113, Heath Miller 8-70, Santonio Holmes 4-52, Mewelde Moore 3-31, Mike Wallace 2-47, Rashard Mendenhall 2-26 |
