| Scoring Summary |
| First Quarter |
| Cleveland Field Goal - 40-yarder by Phil Dawson. |
| Cleveland Field Goal - 33-yarder by Phil Dawson. |
| Second Quarter |
| Cleveland Touchdown - 2-yard run by Joshua Cribbs. (Phil Dawson extra point is good). |
| Buffalo Touchdown - 18-yard pass from Trent Edwards to Marshawn Lynch. (Rian Lindell extra point is good). |
| Third Quarter |
| Cleveland Field Goal - 43-yarder by Phil Dawson. |
| Buffalo Field Goal - 31-yarder by Rian Lindell. |
| Fourth Quarter |
| Cleveland Touchdown - 72-yard run by Jerome Harrison. (Phil Dawson extra point is good). |
| Buffalo Touchdown - 98-yard kickoff return by Leodis McKelvin. (Rian Lindell extra point is good). |
| Individual Statistics |
| Rushing |
| Cleveland |
Jerome Harrison 3-80, Jamal Lewis 18-65, Brady Quinn 4-18, Joshua Cribbs 1-2, Donte Stallworth 1--4 |
| Buffalo |
Marshawn Lynch 23-119, Fred Jackson 12-60, Trent Edwards 3-7 |
| Passing |
| Cleveland |
Brady Quinn (14-36), Yards: 185, Sacked: 1, TD: 0 |
| Buffalo |
Trent Edwards (16-26), Yards: 148, Sacked: 0, TD: 1 |
| Receiving |
| Cleveland |
Braylon Edwards 8-104, Kellen Winslow 3-40, Jerome Harrison 1-21, Charles Ali 1-12, Syndric Steptoe 1-8 |
| Buffalo |
Marshawn Lynch 10-58, Steve Johnson 3-41, Robert Royal 1-22, Roscoe Parrish 1-21, Derek Fine 1-6 |
