| Scoring Summary |
| First Quarter |
| Denver Touchdown - 2-yard run by Jay Cutler. (Matt Prater extra point is good). |
| Denver Field Goal - 23-yarder by Matt Prater. |
| Second Quarter |
| Denver Field Goal - 30-yarder by Matt Prater. |
| Buffalo Field Goal - 37-yarder by Rian Lindell. |
| Third Quarter |
| Buffalo Field Goal - 49-yarder by Rian Lindell. |
| Buffalo Field Goal - 28-yarder by Rian Lindell. |
| Fourth Quarter |
| Buffalo Touchdown - 3-yard pass from Trent Edwards to Steve Johnson. (Rian Lindell extra point is good). |
| Denver Field Goal - 43-yarder by Matt Prater. |
| Individual Statistics |
| Rushing |
| Buffalo |
Fred Jackson 10-43, Marshawn Lynch 11-34, Trent Edwards 2-10, Xavier Omon 2-0, Roscoe Parrish 1-0 |
| Denver |
Eddie Royal 1-71, P.J. Pope 6-44, Jay Cutler 8-30, Tatum Bell 5-20, Selvin Young 7-16 |
| Passing |
| Buffalo |
Trent Edwards (17-25), Yards: 193, Sacked: 1, TD: 1 |
| Denver |
Jay Cutler (25-45), Yards: 359, Sacked: 1, TD: 0 |
| Receiving |
| Buffalo |
Josh Reed 9-79, Fred Jackson 3-70, Lee Evans 2-19, Roscoe Parrish 1-14, Robert Royal 1-8, Steve Johnson 1-3 |
| Denver |
Brandon Marshall 10-129, Eddie Royal 5-57, Daniel Graham 3-52, Brandon Stokley 3-32, Tony Scheffler 2-56, Darrell Jackson 1-30, Tatum Bell 1-3 |
