Microsoft launched the center, focused on developing software solutions for medium- and large-scale businesses, last May.
The expansion of the R&D center at the innovation complex in Moscow will also allow it to develop cross-platform solutions for smartphones and tablet computers, RIA Novosti reported Tuesday.
The expanded cooperation with Skolkovo will reveal "the enormous potential of Russian developers in creating world-class software products," Microsoft chief Steve Ballmer said in a company release.
Microsoft said it would double its Moscow-based workforce by 2015 from its current 70.
Skolkovo has a number of international partners besides Microsoft, including Cisco and Nokia among others, RIA Novosti reported.