The debate will take place at the Creation Museum in Petersburg, Ky., and a live stream of the event expected to attract nearly a million viewers online. Both men have well established views on the topic and are garnering interest and support from both sides.
Ken Ham, a young-Earth creationist who supports a literal interpretation of the Bible, is not new to controversy and has faced intense scrutiny and criticism in the past, at times from the church, for his views that the Bible challenges the very notion of evolution.
Ham started the Answers in Genesis ministry seven years ago, which now attracts nearly half a million visitors annually. The ministry plans to spend more than $60 million on a Noah's Ark biblical theme park in Grant County, about 40 miles from the museum.
"A little fear and trepidation, a little stress," said Ham, in an interview with USA Today. "It's really become something none of us thought it would."
Nye, a proponent of science education and evolution, has asked parents who do not believe in evolution to refrain from influencing their children.
"I say to the grown-ups, if you want to deny evolution and live in your world, in your world that's completely inconsistent with everything we observe in the universe, that's fine," Nye said in a video posted online. "But don't make your kids do it, because we need them."
This will be the first time the two will debate face-to-face. While Ham is feeling the pressure to convince people, he said that ultimately "God does the convincing."