The rocket launch at 12:52 p.m. from the Wallops Flight Facility in Virginia should be visible as far inland as central West Virginia.
The rocket is transporting about 3,300 pounds of supplies to the International Space Station, including space parts, crew provisions and science experiments for the Expedition 40 crew.
The rocket was originally slated to launch Saturday, but poor weather conditions pushed that back to Sunday. The weather office at Wallops said Sunday's conditions are 90 percent favorable for launch.
Should the rocket launch Sunday, it is expected to rendezvous with the ISS on Wednesday.