facebook
twitter
rss
account
search
search
 

Advance in Alzheimer's treatment announced

April 12, 2010 at 4:29 PM   |   Comments

DULUTH, Minn., April 12 (UPI) -- U.S. medical researchers say they have moved one step closer to being able to slow the onset and progression of Alzheimer's disease.

The scientists, in an animal study funded by the National Institute of Environmental Health Sciences, showed that by targeting the blood-brain barrier, they were able to slow the accumulation of a protein associated with the progression of the illness.

The blood-brain barrier separates the brain from circulating blood, they said, protecting the brain by removing toxic metabolites and proteins formed in the brain and preventing entry of toxic chemicals from the blood.

"This study may provide the experimental basis for new strategies that can be used to treat Alzheimer's patients," said David Miller, chief of the NIEHS Laboratory of Toxicology and Pharmacology and an author of the study. "What we've shown in our mouse models is that we can reduce the accumulation of beta-amyloid protein in the brain by targeting a certain receptor in the brain known as the pregnane X receptor, or PXR," said Miller.

The study led by University of Minnesota researcher Anika Hartz included Assistant Professor Bjorn Bauer and appears in the May issue of the journal Molecular Pharmacology.

© 2010 United Press International, Inc. All Rights Reserved. Any reproduction, republication, redistribution and/or modification of any UPI content is expressly prohibited without UPI's prior written consent.
Most Popular
1
6,000-year-old temple discovered in prehistoric Ukraine settlement 6,000-year-old temple discovered in prehistoric Ukraine settlement
2
An ancient tsunami wrecked Hawaii; it could happen again An ancient tsunami wrecked Hawaii; it could happen again
3
NASA orbiter beams back images of Siding Spring comet NASA orbiter beams back images of Siding Spring comet
4
DC drone hobbyists in limbo over flying locations DC drone hobbyists in limbo over flying locations
5
Protestors object plans to build telescope on land sacred to native Hawaiians Protestors object plans to build telescope on land sacred to native Hawaiians
Trending News
Around the Web
x
Feedback