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LOS ANGELES, Dec. 14 (UPI) -- U.S. scientists say they've found the mechanism used by neural stem cells to continue growing and multiplying without changing their stem cell state.
The scientists at the City of Hope National Medical Center in Duarte, Calif., say their discovery establishes a firm foundation for development of safe stem cell therapies.
"One of the biggest challenges to stem cell therapies is simply having enough stem cells," said Assistant ProfessorYanhong Shi, senior author of the study. "We need to know how to expand them in order to apply them to therapies."
Until now, scientists were not sure what signaled neural stem cells -- stem cells that eventually can become nerve and brain cells -- to simply renew themselves and grow without differentiating. Shi and her team say they've found the controlling signal.
The scientists report their research in the early online edition of the journal Nature Cell Biology.
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