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WEST LAFAYETTE, Ind., Dec. 14 (UPI) -- U.S. scientists say they've shown tiny nanoprobes are effective in delivering cancer drugs more directly to tumor cells and the correct cellular compartments.
Purdue University Professor Joseph Irudayaraj and graduate student Jiji Chen said they've determined the nanoprobes, or nanorods, when coated with the breast cancer drug Herceptin, are reaching the endosomes of cells, mimicking the delivery of the drug on its own. Endosomes perform a sorting function to deliver drugs and other substances to the appropriate locations.
"We have demonstrated the ability to track these nanoparticles in different cellular compartments of live cells and show where they collect quantitatively," said Irudayaraj. "Our methods will allow us to calculate the quantities of a drug needed to treat a cancer cell because now we know how these nanoparticles are being distributed to different parts of the cell."
The research appears in the early online edition of the journal Nano.
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