facebook
twitter
rss
account
search
search
 

Chemicals used to disrupt cancer

Feb. 3, 2009 at 12:31 PM   |   Comments

DALLAS, Feb. 3 (UPI) -- U.S. medical scientists have identified two chemical compounds that can possibly disrupt the growth of many types of cancer and degenerative diseases.

University of Texas Southwestern Medical Center researchers screened a chemical library of 200,000 compounds to find the chemicals that can be used to study and possibly manipulate cellular pathways.

"The identification of these chemicals and their targets within this cellular pathway represents an important step in developing therapeutic agents," said Assistant Professor Lawrence Lum.

Using cultured mouse cells, the researchers studied biochemical reactions within cells controlled by a class of proteins called Wnt that help control embryonic development in many animals, including humans. Misregulation of cellular responses to Wnt proteins is associated with a broad range of diseases, including cancer, Alzheimer's and polycystic kidney disease, and type 2 diabetes, the scientists said.

Nine compounds found to inactivate Wnt-controlled systems were earmarked for further research. The scientists found five of the compounds stopped cells from responding to Wnt and four prevented Wnt from being produced in the first place.

The research is reported in the journal Nature Chemical Biology.

© 2009 United Press International, Inc. All Rights Reserved. Any reproduction, republication, redistribution and/or modification of any UPI content is expressly prohibited without UPI's prior written consent.
Most Popular
1
Android phones to join iPhone in saying no to the police Android phones to join iPhone in saying no to the police
2
NASA launches project to get citizens involved in Mars exploration NASA launches project to get citizens involved in Mars exploration
3
Perth's first iPhone buyer immediately drops brand new phone on live TV Perth's first iPhone buyer immediately drops brand new phone on live TV
4
Dogs are the favorite food of leopards in rural India Dogs are the favorite food of leopards in rural India
5
U.S. official warns of the multi-billion dollar cost of climate change U.S. official warns of the multi-billion dollar cost of climate change
Trending News
Video
x
Feedback