Natural cartilage repair in mice studied

Published: July 31, 2008 at 12:09 PM
Order reprints
PORTLAND, Ore., July 31 (UPI) -- U.S. scientists say they're studying mice that can naturally regenerate cartilage to find ways to improve treatment of damaged human cartilage.

Researchers at the Oregon Health & Science University said their study of a strain of mice called MRL/MpJ that has such ability might lead to significant improvements of treatments, such as for Tiger Woods' damaged knee cartilage, as well as human shoulder and hip injuries.

"Human cartilage injuries heal poorly and can lead to cartilage degeneration and osteoarthritis," said Assistant Professor Jamie Fitzgerald. "This is an enormous clinical problem. It is estimated that one-quarter of the adult population will have some kind of arthritis by 2020."

Fitzgerald, Cathleen Rich and Dr. Andrea Herzka studied knee injuries in 150 mice. Three months after the cartilage in their knees was damaged, male MRL mice had replaced a significant amount of the injured tissue with healthy cartilage.

"If we can identify what genes or proteins are necessary for cartilage to heal, we can work toward finding similar genes and proteins in humans," Herzka said. An actual treatment, however, "is many years away."

The study's results were reported in a recent issue of the journal Osteoarthritis and Cartilage.


© 2008 United Press International, Inc. All Rights Reserved.



1,400 die a week in Sri Lankan camp (<1 min)
Speculation grim for North Korea's Kim (12 min)
Tim Hortons chain set to invade New York (18 min)
High insulin level linked to breast cancer (29 min)
Swim club president downplays camp comment (36 min)
Goosen in first at the Scottish Open (37 min)
Walking on sand safer than playing in sand (41 min)
fark
Robert Plant honored with Commander of the British Empire and promises not to boss around Jimmy...
You're worried about losing your job. Do you a) improve your performance, b) look for something...
Teenage hit-and-runner uses Self-Arrest lane to be booked and released in twenty minutes. Would...
Woman's laugh sounds like a car horn
AAA warns motorists to expect 1 of every 100 highway miles to be under construction this summer....
Sign for small Canadian town is hilariously vandalized to advertise certain illicit activity. City...