Blocked gene key to ovulation, study finds

Published: July 18, 2008 at 1:38 PM
Order reprints
MONTREAL, July 18 (UPI) -- New contraception methods and infertility treatments may result from the isolation of a key gene to ovulation, researchers from Canada and Europe said.

Researchers at the University of Montreal discovered how a gene, known as Lrh1, plays an essential role in regulating ovulation and possibly fertilization, Canwest News Service reported Friday.

"This discovery means we can envision new contraceptives that selectively stop ovulation," said Bruce D. Murphy, director of the university's animal research center at the Faculty of Veterinary Medicine.

In their study, scientists "blocked" the gene from cells in the ovaries of genetically modified mice, he said. By removing the gene, they learned hormones were disrupted, preventing eggs from maturing and effectively stopping ovulation.

"If we can target the gene directly, it could be possible to create a contraceptive that would be more effective and produce less side effects than current steroid-based forms of birth control," Murphy said.

The 2 1/2-year study was conducted as a collaborative effort between the University of Montreal and the Louis Pasteur University in Strasbourg, France. The findings were published in the latest edition of Genes and Development.


© 2008 United Press International, Inc. All Rights Reserved.



Cousin: Jacko viewing was open casket (7 min)
Economic Outlook: Huffing about homes (14 min)
Poll: Most want Sotomayor confirmed (19 min)
Nickelodeon not buying La. Six Flags (33 min)
Son of U.N. official kidnapped in Lebanon (34 min)
Jim Carrey to be a grandfather (37 min)
Man gored to death in Pamplona run (38 min)
fark
"Sometimes, you get what you expect. Generally, you meet better people at church than you do at...
They should have known that you can't just walk down the streets of Manhattan dressed as Superman...
The coolest origami city you will see until the artist burns it down. Wait, what?
Budgie will become a hero, and a father, after flying out to sea
Convicted rapist cites fear of having to ingest killer red onions in jail in bid to avoid sentencing....
Over a 30-day period, U.S. Marshalls arrested over 35k fugitives netting 2,356 sex-offenders, 433...