Genetically modified viruses fight cancer

COLUMBUS, Ohio, June 12 (UPI) -- U.S. scientists say they've discovered viruses genetically designed to kill cancer cells might offer a new strategy for treating incurable brain tumors.

Although such viruses are often killed by the body's natural defenses before they can eliminate the tumor, Ohio State University scientists say their research may lead to new ways to use the strategy.

The scientists at OSU's Comprehensive Cancer Center say their research shows that as the viruses destroy the tumor cells, they cause the cells to make proteins that stimulate the growth of new blood vessels to the tumor. Those vessels transport immune cells that eradicate the viruses and actually stimulate re-growth of the tumor.

"This study points to an important side effect of oncolytic viral therapy that may limit its efficacy," said principal investigator Balveen Kaur. "Knowing this, we can now work on designing a combination therapy that will inhibit this effect and enhance the action of the viral therapy."

The study appears in the journal Molecular Therapy.