Brain disease studied at the atomic level

COLUMBUS, Ohio, April 24 (UPI) -- U.S. scientists say they have, for the first time, inspected the atomic level of the protein that causes hereditary cerebral amyloid angiopathy.

The disease, thought to cause stroke and dementia, is initiated by certain kinds of proteins called prions that produce degenerative brain diseases such as CAA, mad cow disease and Creutzfeldt-Jakob disease in humans. All are incurable and fatal.

The researchers, led by Ohio State University Assistant Professor Christopher Jaroniec, used solid-state nuclear magnetic resonance spectroscopy to inspect a tiny portion of the protein molecule that is key to the formation of plaques in blood vessels in the brain.

"This is a very basic study of the structure of the protein and hopefully it will give other researchers the information they need to perform further studies and improve our understanding of CAA," he said.

The research that included doctoral students Jonathan Helmus and Philippe Naudaud, as well as scientists at Case Western Reserve University, appears in the online edition of the Proceedings of the National Academy of Sciences.