Potential diabetes drug target identified

TORONTO, April 15 (UPI) -- Canadian scientists said they have discovered a novel signaling pathway between the gut, brain and liver that lowers blood sugar when it is activated.

The scientists at the Toronto General Hospital Research Institute, led by Dr. Tony Lam, used a rat model to discover that fats can activate a subset of nerves in the intestine, which then send a signal to the brain and subsequently to the liver to lower glucose production.

"This is a new approach in developing more effective methods to lower glucose or blood sugar levels in those who are obese or have diabetes," said Lam. "We already knew that the brain and liver can regulate blood glucose levels, but the question has been, how do you therapeutically target either of these two organs without incurring side effects?

"We may have found a way around this problem by suggesting that the gut can be the initial target instead," he added.

"If new medicines can be developed that stimulate this sensing mechanism in the gut, we may have an effective way of slowing down the body's production of sugar …,"said Lam.

The research appears in the online issue of the journal Science in advance of print publication.