Multiple genes might be linked with lupus

WINSTON-SALEM, N.C., Jan. 21 (UPI) -- A U.S.-led international consortium of scientists has identified multiple genes that are linked with the autoimmune disease systemic lupus erythematosus.

The scientists also confirmed earlier findings linking lupus with several other genes.

"These findings underscore that numerous genes, which are often immune-function related, contribute to the risk of developing lupus," said Wake Forest University researcher Carl Langefeld, the study's senior author and co-director of the International Consortium for Systemic Lupus Erythematosus Genetics.

"These results suggest biologic pathways that help us understand the condition better and suggest additional genetic and non-genetic triggers," added Langefeld. "In addition, they help delineate the genetic distinctions between rheumatoid arthritis, lupus and other autoimmune diseases, which could lead to earlier, more accurate diagnoses."

Systemic lupus can involve the joints, kidneys, heart, lungs, brain and blood and occurs in about 31 of every 100,000 people, affecting women nine times more frequently than men. Scientists believe that lupus is caused by genetic variants that interact with each other and the environment.

The researchers said they are now focusing their attention on specific pathways and genes identified in their study, trying to dissect the precise molecular mechanisms by which the genes contribute to the risk of lupus.